Cog4 | component of oligomeric golgi complex 4
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Behavior/neurological Skeleton Mortality/aging
16 No significant impact
5 Not tested
Data collections
Gene metrics:5Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| embryonic lethality prior to organogenesis | 1 supporting dataset | Cog4em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Cog4em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| decreased bone mineral density | 1 supporting dataset | Cog4em1(IMPC)Bay | heterozygote | Early adult | 3.1x10-5 | ||
| increased bone mineral content | 2 supporting datasets | Cog4em1(IMPC)Bay | heterozygote | Early adult | 5.31x10-7 | ||
| hyperactivity | 1 supporting dataset | Cog4em1(IMPC)Bay | heterozygote | Late adult | 3.17x10-5 |
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Human diseases caused by Cog4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cog4.
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| Cog4em1(IMPC)Bay | Exon Deletion | | mouse |
| Cog4tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cog4tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |