Alg11 | ALG11 alpha-1,2-mannosyltransferase
GeneMGI:2142632
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Vision/eye Behavior/neurological Mortality/aging
15 No significant impact
6 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| decreased grip strength | 2 supporting datasets | Alg11tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.7x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Alg11tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Alg11tm1.1(KOMP)Vlcg | heterozygote | Early adult | 9.49x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Alg11tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Alg11 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Alg11.
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| Alg11tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Alg11tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Alg11tm112029(L1L2_Pgk_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Alg11tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |