Peds1 | plasmanylethanolamine desaturase 1
Physiological systems
17 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Craniofacial
9 No significant impact
7 Not tested
Data collections
Gene metrics:14Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| abnormal retina morphology | 3 supporting datasets | Peds1tm1a(KOMP)Wtsi | homozygote | Early adult | 2.25x10-6 | ||
| decreased hematocrit | 1 supporting dataset | Peds1tm1a(KOMP)Wtsi | homozygote | Early adult | 2.06x10-7 | ||
| decreased bone mineral density | 1 supporting dataset | Peds1tm1a(KOMP)Wtsi | homozygote | Early adult | 4.79x10-5 | ||
| decreased hemoglobin content | 1 supporting dataset | Peds1tm1a(KOMP)Wtsi | homozygote | Early adult | 9.46x10-8 | ||
| abnormal retina pigmentation | 2 supporting datasets | Peds1tm1a(KOMP)Wtsi | homozygote | Early adult | 2.35x10-6 | ||
| decreased circulating calcium level | 1 supporting dataset | Peds1tm1a(KOMP)Wtsi | homozygote | Early adult | 1.62x10-6 | ||
| decreased lean body mass | 1 supporting dataset | Peds1tm1a(KOMP)Wtsi | homozygote | Early adult | 1.18x10-5 | ||
| abnormal eye morphology | 1 supporting dataset | Peds1tm1a(KOMP)Wtsi | homozygote | Early adult | 8.53x10-5 | ||
| increased mean platelet volume | 1 supporting dataset | Peds1tm1a(KOMP)Wtsi | homozygote | Early adult | 1.08x10-19 | ||
| decreased circulating fructosamine level | 1 supporting dataset | Peds1tm1a(KOMP)Wtsi | homozygote | Early adult | 7.66x10-6 |
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| adrenal gland | heterozygote | n/a | 0% (0/1) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Peds1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Peds1.
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| Peds1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Peds1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Peds1tm35635(L1L2_Pgk_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Peds1tm361668(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |