C2cd3 | C2 calcium-dependent domain containing 3

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Reproductive system Immune system Integument Embryo Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging Renal/urinary system

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal embryo size	1 supporting dataset	C2cd3^em1(IMPC)Tcp	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	C2cd3^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
hyperactivity	1 supporting dataset	C2cd3^em1(IMPC)Tcp	heterozygote	Early adult	8.54x10^-11
embryonic growth retardation	1 supporting dataset	C2cd3^em1(IMPC)Tcp	homozygote	E9.5	N/A ^*
abnormal uterus morphology	1 supporting dataset	C2cd3^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
enlarged urinary bladder	1 supporting dataset	C2cd3^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
decreased lymphocyte cell number	1 supporting dataset	C2cd3^em1(IMPC)Tcp	heterozygote	Early adult	4.6x10^-5
embryonic lethality prior to tooth bud stage	1 supporting dataset	C2cd3^em1(IMPC)Tcp	homozygote	E12.5	N/A ^*
increased neutrophil cell number	1 supporting dataset	C2cd3^em1(IMPC)Tcp	heterozygote	Early adult	8.22x10^-7
abnormal skin morphology	1 supporting dataset	C2cd3^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for C2cd3.

Associated images

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Histopathology

There is no histopathology data found for C2cd3.

IMPC related publications

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External links

No external links available for C2cd3.

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*C2cd3^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*C2cd3^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*C2cd3^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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