Ap2s1 | adaptor-related protein complex 2, sigma 1 subunit
GeneMGI:2141861
Physiological systems
20 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Growth/size/body region Digestive/alimentary Mortality/aging
17 No significant impact
4 Not tested
Data collections
Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased body length | 1 supporting dataset | Ap2s1em1(IMPC)Tcp | heterozygote | Early adult | 3.15x10-15 | ||
| abnormal cecum morphology | 1 supporting dataset | Ap2s1em1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| enlarged cecum | 1 supporting dataset | Ap2s1em1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Ap2s1em1(IMPC)Tcp | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Ap2s1em1(IMPC)Tcp | homozygote | E12.5 | N/A * |
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Human diseases caused by Ap2s1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ap2s1.
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| Ap2s1em1(IMPC)Tcp | Intra-exon deletion | | mouse |
| Ap2s1tm1(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Ap2s1tm454684(L1L2_GT0_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |