Prmt6 | protein arginine N-methyltransferase 6
Physiological systems
18 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Vision/eye Hematopoietic system Cardiovascular system
12 No significant impact
6 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased heart left ventricle size | 1 supporting dataset | Prmt6em1(IMPC)Marc | homozygote | Early adult | 2.33x10-5 | ||
| increased eosinophil cell number | 2 supporting datasets | Prmt6em1(IMPC)Marc | homozygote | Early adult | 1.32x10-18 | ||
| male infertility | 1 supporting dataset | Prmt6em1(IMPC)Marc | homozygote | Early adult | N/A * | ||
| increased circulating creatinine level | 1 supporting dataset | Prmt6em1(IMPC)Marc | homozygote | Early adult | 3.94x10-5 | ||
| abnormal retina morphology | 1 supporting dataset | Prmt6em1(IMPC)Marc | homozygote | Early adult | 5.37x10-5 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Prmt6em1(IMPC)Marc | homozygote | Early adult | 8.53x10-6 | ||
| increased basophil cell number | 2 supporting datasets | Prmt6em1(IMPC)Marc | homozygote | Early adult | 1.77x10-14 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Prmt6em1(IMPC)Marc | homozygote | Early adult | 4.72x10-5 |
| | | | | | | | | | |
Human diseases caused by Prmt6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Prmt6.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Prmt6em1(IMPC)Marc | Deletion | | mouse |