Prmt6 | protein arginine N-methyltransferase 6

GeneMGI:2139971Synonyms: Hrmt1l6

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Immune system Vision/eye Hematopoietic system Cardiovascular system

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased heart left ventricle size1 supporting datasetPrmt6em1(IMPC)MarchomozygoteEarly adult2.33x10-5 
increased eosinophil cell number2 supporting datasetsPrmt6em1(IMPC)MarchomozygoteEarly adult1.32x10-18 
male infertility1 supporting datasetPrmt6em1(IMPC)MarchomozygoteEarly adultN/A * 
increased circulating creatinine level1 supporting datasetPrmt6em1(IMPC)MarchomozygoteEarly adult3.94x10-5 
abnormal retina morphology1 supporting datasetPrmt6em1(IMPC)MarchomozygoteEarly adult5.37x10-5 
increased circulating alanine transaminase level1 supporting datasetPrmt6em1(IMPC)MarchomozygoteEarly adult8.53x10-6 
increased basophil cell number2 supporting datasetsPrmt6em1(IMPC)MarchomozygoteEarly adult1.77x10-14 
increased circulating aspartate transaminase level1 supporting datasetPrmt6em1(IMPC)MarchomozygoteEarly adult4.72x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Prmt6em1(IMPC)MarcDeletionmouse

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