Usp53 | ubiquitin specific peptidase 53
Physiological systems
17 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Hearing/vestibular/ear Nervous system Behavior/neurological Skeleton Cardiovascular system
10 No significant impact
7 Not tested
Data collections
Gene metrics:13Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating alkaline phosphatase level | 1 supporting dataset | Usp53em1(IMPC)Tcp | homozygote | Early adult | 8.15x10-14 | ||
| decreased prepulse inhibition | 7 supporting datasets | Usp53em1(IMPC)Tcp | homozygote | Early adult | 2.47x10-82 | ||
| decreased bone mineral content | 2 supporting datasets | Usp53em1(IMPC)Tcp | homozygote | Early adult | 1.41x10-14 | ||
| decreased bone mineral density | 1 supporting dataset | Usp53em1(IMPC)Tcp | homozygote | Early adult | 5.21x10-13 | ||
| abnormal auditory brainstem response | 6 supporting datasets | Usp53em1(IMPC)Tcp | homozygote | Early adult | 2.77x10-9 | ||
| abnormal startle reflex | 1 supporting dataset | Usp53em1(IMPC)Tcp | homozygote | Early adult | 2x10-19 | ||
| prolonged PR interval | 1 supporting dataset | Usp53em1(IMPC)Tcp | homozygote | Early adult | 2.08x10-11 | ||
| increased circulating cholesterol level | 1 supporting dataset | Usp53em1(IMPC)Tcp | homozygote | Early adult | 1.78x10-5 | ||
| increased circulating bilirubin level | 1 supporting dataset | Usp53em1(IMPC)Tcp | homozygote | Early adult | 7.16x10-13 | ||
| decreased startle reflex | 1 supporting dataset | Usp53em1(IMPC)Tcp | homozygote | Early adult | 7.11x10-6 |
| | | | | | | | | | |
Human diseases caused by Usp53 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Usp53.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Usp53em1(IMPC)Tcp | Exon Deletion | | mouse |
| Usp53tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Usp53tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |