Usp53 | ubiquitin specific peptidase 53

GeneMGI:2139607Synonyms: Sp6, Phxr3, +1 more

Physiological systems

17 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Hearing/vestibular/ear Nervous system Behavior/neurological Skeleton Cardiovascular system

10 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating alkaline phosphatase level	1 supporting dataset	Usp53^em1(IMPC)Tcp	homozygote	Early adult	8.15x10^-14
decreased prepulse inhibition	7 supporting datasets	Usp53^em1(IMPC)Tcp	homozygote	Early adult	2.47x10^-82
decreased bone mineral content	2 supporting datasets	Usp53^em1(IMPC)Tcp	homozygote	Early adult	1.41x10^-14
decreased bone mineral density	1 supporting dataset	Usp53^em1(IMPC)Tcp	homozygote	Early adult	5.21x10^-13
abnormal auditory brainstem response	6 supporting datasets	Usp53^em1(IMPC)Tcp	homozygote	Early adult	2.77x10^-9
abnormal startle reflex	1 supporting dataset	Usp53^em1(IMPC)Tcp	homozygote	Early adult	2x10^-19
prolonged PR interval	1 supporting dataset	Usp53^em1(IMPC)Tcp	homozygote	Early adult	2.08x10^-11
increased circulating cholesterol level	1 supporting dataset	Usp53^em1(IMPC)Tcp	homozygote	Early adult	1.78x10^-5
increased circulating bilirubin level	1 supporting dataset	Usp53^em1(IMPC)Tcp	homozygote	Early adult	7.16x10^-13
decreased startle reflex	1 supporting dataset	Usp53^em1(IMPC)Tcp	homozygote	Early adult	7.11x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Usp53.

Associated images

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Histopathology

There is no histopathology data found for Usp53.

IMPC related publications

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External links

No external links available for Usp53.

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*Usp53^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Usp53^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Usp53^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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