Dzank1 | double zinc ribbon and ankyrin repeat domains 1

GeneMGI:2139080Synonyms: Ankrd64, 2810039F03Rik, +1 more

Physiological systems

21 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Vision/eye Behavior/neurological Cardiovascular system

18 No significant impact

3 Not tested

Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

eye hemorrhage1 supporting datasetDzank1tm1b(KOMP)WtsihomozygoteEarly adult4.57x10-7 
increased vertical activity1 supporting datasetDzank1tm1b(KOMP)WtsihomozygoteEarly adult6.52x10-10 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/4)0.7% (4/570)
aortaheterozygoten/a0% (0/4)0.19% (1/533)
bloodheterozygoten/a0% (0/2)0% (0/17)
bone marrowheterozygoten/a0% (0/1)0% (0/22)
brainheterozygoteWholemount images
100% (4/4)0.86% (5/579)
brainstemheterozygoten/an/a0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/4)0% (0/588)
cartilage tissueheterozygoten/an/a0.22% (1/454)
cecumheterozygoten/a50% (2/4)7.75% (22/284)
cerebellumheterozygoteSection images
Wholemount images
100% (4/4)0.56% (3/532)
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Histopathology

IMPC related publications

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Dzank1tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Dzank1tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Dzank1tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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