Tmem237 | transmembrane protein 237

GeneMGI:2138365Synonyms: Als2cr4, LOC381259

Physiological systems

20 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging Cardiovascular system

7 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:23Significant phenotypes

5Associated diseases

Expression examined in:78Adult tissues

36Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal testis morphology	1 supporting dataset	Tmem237^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
abnormal adrenal gland morphology	1 supporting dataset	Tmem237^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
abnormal lymph node morphology	1 supporting dataset	Tmem237^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
abnormal brain morphology	2 supporting datasets	Tmem237^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
increased circulating triglyceride level	1 supporting dataset	Tmem237^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.99x10^-37
increased circulating calcium level	1 supporting dataset	Tmem237^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.75x10^-9
enlarged heart	2 supporting datasets	Tmem237^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
abnormal heart morphology	2 supporting datasets	Tmem237^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
small testis	1 supporting dataset	Tmem237^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
increased circulating aspartate transaminase level	1 supporting dataset	Tmem237^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.73x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tmem237.

Associated images

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Histopathology

There is no histopathology data found for Tmem237.

IMPC related publications

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External links

No external links available for Tmem237.

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*Tmem237^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Tmem237^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tmem237^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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