Tmem237 | transmembrane protein 237
Physiological systems
20 / 24 physiological systems tested
13 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging Cardiovascular system
7 No significant impact
4 Not tested
Data collections
Gene metrics:23Significant phenotypes
5Associated diseases
Expression examined in:78Adult tissues
36Embryo tissues
| abnormal testis morphology | 1 supporting dataset | Tmem237tm1b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| abnormal adrenal gland morphology | 1 supporting dataset | Tmem237tm1b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| abnormal lymph node morphology | 1 supporting dataset | Tmem237tm1b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| abnormal brain morphology | 2 supporting datasets | Tmem237tm1b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| increased circulating triglyceride level | 1 supporting dataset | Tmem237tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.99x10-37 | ||
| increased circulating calcium level | 1 supporting dataset | Tmem237tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.75x10-9 | ||
| enlarged heart | 2 supporting datasets | Tmem237tm1b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| abnormal heart morphology | 2 supporting datasets | Tmem237tm1b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| small testis | 1 supporting dataset | Tmem237tm1b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Tmem237tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.73x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | n/a | 0% (0/17) |
| bone | heterozygote | Section images | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | n/a | 0% (0/22) |
| brain | heterozygote | Section images | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | Section images | 0% (0/2) | 7.75% (22/284) |
Human diseases caused by Tmem237 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tmem237.
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| Tmem237tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tmem237tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Tmem237tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |