Dtnbp1 | dystrobrevin binding protein 1

GeneMGI:2137586Synonyms: sdy, Bloc1s8, +2 more

Physiological systems

17 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Pigmentation Immune system Integument Vision/eye Hematopoietic system Behavior/neurological Mortality/aging

8 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased neutrophil cell number	2 supporting datasets	Dtnbp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.07x10^-12
increased leukocyte cell number	1 supporting dataset	Dtnbp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.12x10^-8
abnormal iris pigmentation	1 supporting dataset	Dtnbp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.42x10^-19
decreased lymphocyte cell number	1 supporting dataset	Dtnbp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.1x10^-7
abnormal retina morphology	1 supporting dataset	Dtnbp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.86x10^-13
abnormal uterus morphology	1 supporting dataset	Dtnbp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased lymphocyte cell number	1 supporting dataset	Dtnbp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.36x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Dtnbp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal coat/hair pigmentation	3 supporting datasets	Dtnbp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2x10^-19
decreased grip strength	1 supporting dataset	Dtnbp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.02x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dtnbp1.

Associated images

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Histopathology

There is no histopathology data found for Dtnbp1.

IMPC related publications

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External links

No external links available for Dtnbp1.

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*Dtnbp1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Dtnbp1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Dtnbp1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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