Dtnbp1 | dystrobrevin binding protein 1
Physiological systems
17 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Pigmentation Immune system Integument Vision/eye Hematopoietic system Behavior/neurological Mortality/aging
8 No significant impact
7 Not tested
Data collections
Gene metrics:12Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased neutrophil cell number | 2 supporting datasets | Dtnbp1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.07x10-12 | ||
| increased leukocyte cell number | 1 supporting dataset | Dtnbp1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.12x10-8 | ||
| abnormal iris pigmentation | 1 supporting dataset | Dtnbp1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.42x10-19 | ||
| decreased lymphocyte cell number | 1 supporting dataset | Dtnbp1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.1x10-7 | ||
| abnormal retina morphology | 1 supporting dataset | Dtnbp1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.86x10-13 | ||
| abnormal uterus morphology | 1 supporting dataset | Dtnbp1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased lymphocyte cell number | 1 supporting dataset | Dtnbp1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.36x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Dtnbp1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal coat/hair pigmentation | 3 supporting datasets | Dtnbp1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2x10-19 | ||
| decreased grip strength | 1 supporting dataset | Dtnbp1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.02x10-5 |
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Human diseases caused by Dtnbp1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Dtnbp1.
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| Dtnbp1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dtnbp1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Dtnbp1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |