Aff4 | AF4/FMR2 family, member 4
Physiological systems
22 / 24 physiological systems tested
12 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Embryo Growth/size/body region Limbs/digits/tail Vision/eye Behavior/neurological Skeleton Mortality/aging Craniofacial Cardiovascular system Renal/urinary system
10 No significant impact
2 Not tested
Data collections
Gene metrics:15Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal blood vessel morphology | 1 supporting dataset | Aff4em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| increased grip strength | 1 supporting dataset | Aff4em1(IMPC)Mbp | heterozygote | Early adult | 4.76x10-5 | ||
| abnormal caudal vertebrae morphology | 1 supporting dataset | Aff4em1(IMPC)Mbp | heterozygote | Early adult | 1.19x10-6 | ||
| increased freezing behavior | 1 supporting dataset | Aff4em1(IMPC)Mbp | heterozygote | Early adult | 7.88x10-8 | ||
| abnormal kidney morphology | 1 supporting dataset | Aff4em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| anophthalmia | 1 supporting dataset | Aff4em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| small kidney | 1 supporting dataset | Aff4em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal placenta morphology | 1 supporting dataset | Aff4em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| microphthalmia | 1 supporting dataset | Aff4em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Aff4em1(IMPC)Mbp | homozygote | Early adult | N/A * |
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Human diseases caused by Aff4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Aff4.
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| Aff4em1(IMPC)Mbp | Exon Deletion | | mouse |