Aff4 | AF4/FMR2 family, member 4
Physiological systems
22 / 24 physiological systems tested
12 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Embryo Growth/size/body region Limbs/digits/tail Vision/eye Behavior/neurological Skeleton Mortality/aging Craniofacial Cardiovascular system Renal/urinary system
10 No significant impact
2 Not tested
Data collections
Gene metrics:15Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal blood vessel morphology | 1 supporting dataset | Aff4em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| increased grip strength | 1 supporting dataset | Aff4em1(IMPC)Mbp | heterozygote | Early adult | 4.76x10-5 | ||
| abnormal caudal vertebrae morphology | 1 supporting dataset | Aff4em1(IMPC)Mbp | heterozygote | Early adult | 1.19x10-6 | ||
| increased freezing behavior | 1 supporting dataset | Aff4em1(IMPC)Mbp | heterozygote | Early adult | 7.88x10-8 | ||
| abnormal kidney morphology | 1 supporting dataset | Aff4em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| anophthalmia | 1 supporting dataset | Aff4em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| small kidney | 1 supporting dataset | Aff4em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal placenta morphology | 1 supporting dataset | Aff4em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| microphthalmia | 1 supporting dataset | Aff4em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Aff4em1(IMPC)Mbp | homozygote | Early adult | N/A * |
| | | | | | | | | | |
External links
No external links available for Aff4.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Aff4em1(IMPC)Mbp | Exon Deletion | | mouse |