Dync1li1 | dynein cytoplasmic 1 light intermediate chain 1

GeneMGI:2135610Synonyms: LIC-1, Dnclic1, +2 more

Physiological systems

22 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Vision/eye Respiratory system Liver/biliary system Hematopoietic system Skeleton Mortality/aging Cardiovascular system Renal/urinary system

10 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal skin morphology	1 supporting dataset	Dync1li1^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
abnormal lung morphology	1 supporting dataset	Dync1li1^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
enlarged lymph nodes	1 supporting dataset	Dync1li1^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
microphthalmia	1 supporting dataset	Dync1li1^em1(IMPC)Tcp	homozygote	E15.5	N/A ^*
increased red blood cell distribution width	1 supporting dataset	Dync1li1^em1(IMPC)Tcp	heterozygote	Early adult	3.8x10^-5
abnormal liver morphology	1 supporting dataset	Dync1li1^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Dync1li1^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
abnormal seminal vesicle morphology	1 supporting dataset	Dync1li1^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
abnormal seminal vesicle morphology	1 supporting dataset	Dync1li1^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
preweaning lethality, incomplete penetrance	3 supporting datasets	Dync1li1^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dync1li1.

Associated images

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Histopathology

There is no histopathology data found for Dync1li1.

IMPC related publications

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External links

No external links available for Dync1li1.

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*Dync1li1^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Dync1li1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dync1li1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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