Sirt1 | sirtuin 1

GeneMGI:2135607Synonyms: Sir2alpha, Sir2

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Immune system Growth/size/body region Vision/eye Hematopoietic system Skeleton Craniofacial Cardiovascular system Mortality/aging

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased basophil cell number	2 supporting datasets	Sirt1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.63x10^-12
abnormal scapula morphology	1 supporting dataset	Sirt1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.33x10^-5
abnormal sinus arrhythmia	1 supporting dataset	Sirt1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	8.74x10^-9
abnormal tooth morphology	1 supporting dataset	Sirt1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.29x10^-6
abnormal iris morphology	1 supporting dataset	Sirt1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.89x10^-6
abnormal snout morphology	1 supporting dataset	Sirt1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.9x10^-5
abnormal pelvic girdle bone morphology	1 supporting dataset	Sirt1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	8.03x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Sirt1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal maxilla morphology	1 supporting dataset	Sirt1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.08x10^-5
narrow eye opening	1 supporting dataset	Sirt1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.87x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Sirt1.

Associated images

Loading...

Histopathology

There is no histopathology data found for Sirt1.

IMPC related publications

Loading...

External links

No external links available for Sirt1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Sirt1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Sirt1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Sirt1^{tm1c(EUCOMM)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Sirt1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

My Genes