Sez6l | seizure related 6 homolog like
Physiological systems
19 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological
17 No significant impact
5 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| decreased exploration in new environment | 1 supporting dataset | Sez6ltm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.2x10-16 | ||
| decreased locomotor activity | 8 supporting datasets | Sez6ltm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.02x10-12 | ||
| abnormal gait | 1 supporting dataset | Sez6ltm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.26x10-5 | ||
| increased anxiety-related response | 1 supporting dataset | Sez6ltm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.76x10-7 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Sez6ltm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.35x10-7 | ||
| increased thigmotaxis | 2 supporting datasets | Sez6ltm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.97x10-6 | ||
| abnormal behavior | 1 supporting dataset | Sez6ltm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.72x10-5 | ||
| decreased respiratory quotient | 1 supporting dataset | Sez6ltm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.96x10-7 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Sez6ltm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.83x10-8 |
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| adrenal gland | heterozygote | n/a | 0% (0/3) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/3) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/3) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (3/3) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/3) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/3) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/3) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/3) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/3) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/3) | 1.67% (7/419) |
Human diseases caused by Sez6l mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Sez6l.
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| Sez6ltm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Sez6ltm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Sez6ltm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Sez6ltm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |