Sez6l | seizure related 6 homolog like

GeneMGI:1935121Synonyms: Acig1

Physiological systems

19 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Behavior/neurological

17 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



decreased exploration in new environment	1 supporting dataset	Sez6l^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.2x10^-16
decreased locomotor activity	8 supporting datasets	Sez6l^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.02x10^-12
abnormal gait	1 supporting dataset	Sez6l^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.26x10^-5
increased anxiety-related response	1 supporting dataset	Sez6l^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.76x10^-7
decreased circulating serum albumin level	1 supporting dataset	Sez6l^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.35x10^-7
increased thigmotaxis	2 supporting datasets	Sez6l^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.97x10^-6
abnormal behavior	1 supporting dataset	Sez6l^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.72x10^-5
decreased respiratory quotient	1 supporting dataset	Sez6l^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.96x10^-7
increased circulating alkaline phosphatase level	1 supporting dataset	Sez6l^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.83x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sez6l.

Associated images

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Histopathology

There is no histopathology data found for Sez6l.

IMPC related publications

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External links

No external links available for Sez6l.

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*Sez6l^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Sez6l^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Sez6l^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Sez6l^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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