Tm6sf2 | transmembrane 6 superfamily member 2

GeneMGI:1933210

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system

16 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



increased circulating alanine transaminase level	1 supporting dataset	Tm6sf2^{tm1b(KOMP)Wtsi}	homozygote	Late adult	3.21x10^-19
thrombocytopenia	1 supporting dataset	Tm6sf2^{tm1b(KOMP)Wtsi}	homozygote	Late adult	1.06x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Tm6sf2^{tm1b(KOMP)Wtsi}	homozygote	Late adult	6.1x10^-29
decreased circulating cholesterol level	1 supporting dataset	Tm6sf2^{tm1b(KOMP)Wtsi}	homozygote	Late adult	8.37x10^-6
decreased circulating HDL cholesterol level	1 supporting dataset	Tm6sf2^{tm1b(KOMP)Wtsi}	homozygote	Late adult	1.65x10^-5
increased circulating iron level	1 supporting dataset	Tm6sf2^{tm1b(KOMP)Wtsi}	homozygote	Late adult	2.27x10^-5
decreased circulating alkaline phosphatase level	1 supporting dataset	Tm6sf2^{tm1b(KOMP)Wtsi}	homozygote	Late adult	6.34x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Tm6sf2.

Associated images

Loading...

Histopathology

There is no histopathology data found for Tm6sf2.

IMPC related publications

Loading...

External links

No external links available for Tm6sf2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Tm6sf2^em1(IMPC)H*	Indel	‌	mouse
*Tm6sf2^em3(IMPC)H*	Exon Deletion	‌	mouse
*Tm6sf2^em4(IMPC)H*	Exon Deletion	‌	mouse
*Tm6sf2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Tm6sf2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tm6sf2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Tm6sf2^{tm45537(L1L2_Pgk_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes