Tm6sf2 | transmembrane 6 superfamily member 2

GeneMGI:1933210

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system

16 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



increased circulating alanine transaminase level	1 supporting dataset	Tm6sf2^{tm1b(KOMP)Wtsi}	homozygote	Late adult	3.21x10^-19
thrombocytopenia	1 supporting dataset	Tm6sf2^{tm1b(KOMP)Wtsi}	homozygote	Late adult	1.06x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Tm6sf2^{tm1b(KOMP)Wtsi}	homozygote	Late adult	6.1x10^-29
decreased circulating cholesterol level	1 supporting dataset	Tm6sf2^{tm1b(KOMP)Wtsi}	homozygote	Late adult	8.37x10^-6
decreased circulating HDL cholesterol level	1 supporting dataset	Tm6sf2^{tm1b(KOMP)Wtsi}	homozygote	Late adult	1.65x10^-5
increased circulating iron level	1 supporting dataset	Tm6sf2^{tm1b(KOMP)Wtsi}	homozygote	Late adult	2.27x10^-5
decreased circulating alkaline phosphatase level	1 supporting dataset	Tm6sf2^{tm1b(KOMP)Wtsi}	homozygote	Late adult	6.34x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tm6sf2.

Associated images

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Histopathology

There is no histopathology data found for Tm6sf2.

IMPC related publications

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External links

No external links available for Tm6sf2.

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*Tm6sf2^em1(IMPC)H*	Indel	‌	mouse
*Tm6sf2^em3(IMPC)H*	Exon Deletion	‌	mouse
*Tm6sf2^em4(IMPC)H*	Exon Deletion	‌	mouse
*Tm6sf2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Tm6sf2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tm6sf2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Tm6sf2^{tm45537(L1L2_Pgk_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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