Grin3a | glutamate receptor ionotropic, NMDA3A
Physiological systems
19 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Reproductive system
18 No significant impact
5 Not tested
Data collections
Gene metrics:1Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| abnormal epididymis morphology | 1 supporting dataset | Grin3atm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Grin3a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Grin3a.
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| Grin3atm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Grin3atm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Grin3atm1c(EUCOMM)Hmgu | Wild type floxed exon (post-Flp) | | mouse |
| Grin3atm388(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Grin3atm388(L1L2_st0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |