Setbp1 | SET binding protein 1
Physiological systems
17 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological Mortality/aging
14 No significant impact
7 Not tested
Data collections
Gene metrics:3Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
22Embryo tissues
| decreased circulating cholesterol level | 1 supporting dataset | Setbp1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.11x10-5 | ||
| abnormal vocalization | 1 supporting dataset | Setbp1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.45x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Setbp1tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
Human diseases caused by Setbp1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Setbp1.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Setbp1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Setbp1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Setbp1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |