Abtb1 | ankyrin repeat and BTB domain containing 1
Physiological systems
21 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Integument Growth/size/body region Hematopoietic system Cardiovascular system
15 No significant impact
3 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal skin morphology | 1 supporting dataset | Abtb1em1(IMPC)Ccpcz | homozygote | Early adult | 4.08x10-5 | ||
| abnormal heart morphology | 1 supporting dataset | Abtb1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased fasting circulating glucose level | 1 supporting dataset | Abtb1em1(IMPC)Ccpcz | homozygote | Early adult | 6.15x10-5 | ||
| enlarged heart | 1 supporting dataset | Abtb1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged spleen | 1 supporting dataset | Abtb1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Abtb1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * |
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Human diseases caused by Abtb1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Abtb1.
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| Abtb1em1(IMPC)Ccpcz | Intra-exon deletion | | mouse |
| Abtb1tm95114(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |