Clcnkb | chloride channel, voltage-sensitive Kb
Physiological systems
21 / 24 physiological systems tested
14 Significantly impacted by the knock-out
Reproductive system Immune system Integument Endocrine/exocrine gland Adipose tissue Growth/size/body region Digestive/alimentary Hematopoietic system Cardiovascular system Renal/urinary system Homeostasis/metabolism Liver/biliary system Behavior/neurological Skeleton
7 No significant impact
3 Not tested
Data collections
Gene metrics:43Significant phenotypes
7Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal heart morphology | 2 supporting datasets | Clcnkbem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal lymph node morphology | 2 supporting datasets | Clcnkbem1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| increased blood urea nitrogen level | 1 supporting dataset | Clcnkbem1(IMPC)Mbp | homozygote | Late adult | 6.72x10-12 | ||
| increased circulating cholesterol level | 1 supporting dataset | Clcnkbem1(IMPC)Mbp | homozygote | Late adult | 1.15x10-8 | ||
| increased grip strength | 2 supporting datasets | Clcnkbem1(IMPC)Mbp | homozygote | Late adult | 5.29x10-7 | ||
| decreased heart weight | 2 supporting datasets | Clcnkbem1(IMPC)Mbp | homozygote | Early adult | 6.84x10-11 | ||
| abnormal cholesterol homeostasis | 1 supporting dataset | Clcnkbem1(IMPC)Mbp | homozygote | Late adult | 7.89x10-8 | ||
| abnormal skin morphology | 1 supporting dataset | Clcnkbem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| small heart | 2 supporting datasets | Clcnkbem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal kidney morphology | 2 supporting datasets | Clcnkbem1(IMPC)Mbp | homozygote | Late adult | N/A * |
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Human diseases caused by Clcnkb mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Clcnkb.
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| Clcnkbem1(IMPC)Mbp | Exon Deletion | | mouse |
| Clcnkbtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Clcnkbtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |