Clcnkb | chloride channel, voltage-sensitive Kb

GeneMGI:1930643Synonyms: Clck2, ClC-K2, +2 more

Physiological systems

21 / 24 physiological systems tested

14 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Adipose tissue Growth/size/body region Digestive/alimentary Hematopoietic system Cardiovascular system Renal/urinary system Homeostasis/metabolism Liver/biliary system Behavior/neurological Skeleton

7 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:43Significant phenotypes

7Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal heart morphology	2 supporting datasets	Clcnkb^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal lymph node morphology	2 supporting datasets	Clcnkb^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
increased blood urea nitrogen level	1 supporting dataset	Clcnkb^em1(IMPC)Mbp	homozygote	Late adult	6.72x10^-12
increased circulating cholesterol level	1 supporting dataset	Clcnkb^em1(IMPC)Mbp	homozygote	Late adult	1.15x10^-8
increased grip strength	2 supporting datasets	Clcnkb^em1(IMPC)Mbp	homozygote	Late adult	5.29x10^-7
decreased heart weight	2 supporting datasets	Clcnkb^em1(IMPC)Mbp	homozygote	Early adult	6.84x10^-11
abnormal cholesterol homeostasis	1 supporting dataset	Clcnkb^em1(IMPC)Mbp	homozygote	Late adult	7.89x10^-8
abnormal skin morphology	1 supporting dataset	Clcnkb^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
small heart	2 supporting datasets	Clcnkb^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal kidney morphology	2 supporting datasets	Clcnkb^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Clcnkb.

Associated images

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Histopathology

There is no histopathology data found for Clcnkb.

IMPC related publications

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External links

No external links available for Clcnkb.

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*Clcnkb^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Clcnkb^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Clcnkb^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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