Srd5a3 | steroid 5 alpha-reductase 3
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Embryo Growth/size/body region Limbs/digits/tail Hearing/vestibular/ear Mortality/aging
14 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
3Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| abnormal tail bud morphology | 1 supporting dataset | Srd5a3tm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Srd5a3tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Srd5a3tm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * | ||
| abnormal auditory brainstem response | 1 supporting dataset | Srd5a3tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.61x10-6 | ||
| abnormal embryo turning | 1 supporting dataset | Srd5a3tm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Srd5a3tm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Srd5a3tm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * |
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External links
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| Srd5a3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Srd5a3tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Srd5a3tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Srd5a3tm43607(L1L2_st2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |