Srd5a3 | steroid 5 alpha-reductase 3
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Embryo Growth/size/body region Limbs/digits/tail Hearing/vestibular/ear Mortality/aging
14 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
3Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| abnormal tail bud morphology | 1 supporting dataset | Srd5a3tm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Srd5a3tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Srd5a3tm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * | ||
| abnormal auditory brainstem response | 1 supporting dataset | Srd5a3tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.61x10-6 | ||
| abnormal embryo turning | 1 supporting dataset | Srd5a3tm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Srd5a3tm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Srd5a3tm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Srd5a3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Srd5a3.
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| Srd5a3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Srd5a3tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Srd5a3tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Srd5a3tm43607(L1L2_st2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |