Trpm7 | transient receptor potential cation channel, subfamily M, member 7
Physiological systems
17 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Mortality/aging
14 No significant impact
7 Not tested
Data collections
Gene metrics:4Significant phenotypes
3Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| thrombocytosis | 1 supporting dataset | Trpm7tm1b(KOMP)Wtsi | heterozygote | Early adult | 2.69x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Trpm7tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Trpm7tm1b(KOMP)Wtsi | heterozygote | Early adult | 6.88x10-12 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Trpm7tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 50% (1/2) | 1.67% (7/419) |
Human diseases caused by Trpm7 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Trpm7.
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| Trpm7tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Trpm7tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Trpm7tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Trpm7tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Trpm7tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Trpm7tm44236(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |