Smoc1 | SPARC related modular calcium binding 1
Physiological systems
22 / 24 physiological systems tested
14 Significantly impacted by the knock-out
Immune system Integument Growth/size/body region Hematopoietic system Cardiovascular system Craniofacial Homeostasis/metabolism Pigmentation Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging
8 No significant impact
2 Not tested
Gene metrics:27Significant phenotypes
2Associated diseases
Expression examined in:92Adult tissues
0Embryo tissues
| short tibia | 1 supporting dataset | Smoc1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 0 | ||
| abnormal digit morphology | 5 supporting datasets | Smoc1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.7x10-10 | ||
| abnormal retina morphology | 1 supporting dataset | Smoc1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 7.19x10-6 | ||
| narrow eye opening | 1 supporting dataset | Smoc1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 6.09x10-11 | ||
| abnormal head size | 1 supporting dataset | Smoc1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.87x10-8 | ||
| abnormal optic disk morphology | 1 supporting dataset | Smoc1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.28x10-10 | ||
| abnormal pelvic girdle bone morphology | 1 supporting dataset | Smoc1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.59x10-6 | ||
| mydriasis | 1 supporting dataset | Smoc1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.41x10-6 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Smoc1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.48x10-7 | ||
| increased basophil cell number | 2 supporting datasets | Smoc1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.14x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (1/1) | 0.7% (4/570) |
| adrenal gland | homozygote | n/a | 100% (1/1) | 0.7% (4/570) |
| aorta | homozygote | n/a | 100% (1/1) | 0.19% (1/533) |
| aorta | heterozygote | n/a | 100% (1/1) | 0.19% (1/533) |
| bone | homozygote | n/a | 0% (0/1) | 0% (0/394) |
| bone | heterozygote | n/a | 0% (0/1) | 0% (0/394) |
| brain | homozygote | n/a | 100% (1/1) | 0.86% (5/579) |
| brain | heterozygote | n/a | 100% (1/1) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/1) | 0.41% (2/490) |
| brainstem | homozygote | n/a | 0% (0/1) | 0.41% (2/490) |
Human diseases caused by Smoc1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Smoc1.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Smoc1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Smoc1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Smoc1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |