Smoc1 | SPARC related modular calcium binding 1

GeneMGI:1929878Synonyms: SPARC-related protein, 2600002F22Rik, +1 more

Physiological systems

22 / 24 physiological systems tested

14 Significantly impacted by the knock-out

Immune system Integument Growth/size/body region Hematopoietic system Cardiovascular system Craniofacial Homeostasis/metabolism Pigmentation Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging

8 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:27Significant phenotypes

2Associated diseases

Expression examined in:92Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



short tibia	1 supporting dataset	Smoc1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	0
abnormal digit morphology	5 supporting datasets	Smoc1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.7x10^-10
abnormal retina morphology	1 supporting dataset	Smoc1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.19x10^-6
narrow eye opening	1 supporting dataset	Smoc1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.09x10^-11
abnormal head size	1 supporting dataset	Smoc1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.87x10^-8
abnormal optic disk morphology	1 supporting dataset	Smoc1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.28x10^-10
abnormal pelvic girdle bone morphology	1 supporting dataset	Smoc1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.59x10^-6
mydriasis	1 supporting dataset	Smoc1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.41x10^-6
abnormal retina blood vessel morphology	1 supporting dataset	Smoc1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.48x10^-7
increased basophil cell number	2 supporting datasets	Smoc1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.14x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Smoc1.

Associated images

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Histopathology

There is no histopathology data found for Smoc1.

IMPC related publications

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External links

No external links available for Smoc1.

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*Smoc1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Smoc1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Smoc1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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