Mogs | mannosyl-oligosaccharide glucosidase

GeneMGI:1929872Synonyms: Gcs1, 1810017N02Rik

Physiological systems

21 / 24 physiological systems tested

10 Significantly impacted by the knock-out

 Immune system Endocrine/exocrine gland Integument Digestive/alimentary Limbs/digits/tail Vision/eye Respiratory system Hematopoietic system Skeleton Mortality/aging

11 No significant impact

3 Not tested

Gene metrics:13Significant phenotypes
2Associated diseases
Expression examined in:51Adult tissues
62Embryo tissues

Phenotypes

anophthalmia2 supporting datasetsMogstm1(KOMP)VlcgheterozygoteEarly adultN/A * 
enlarged thymus1 supporting datasetMogstm1(KOMP)VlcgheterozygoteEarly adultN/A * 
abnormal trachea morphology2 supporting datasetsMogstm1(KOMP)VlcgheterozygoteEarly adultN/A * 
abnormal thyroid gland morphology2 supporting datasetsMogstm1(KOMP)VlcgheterozygoteEarly adultN/A * 
absent adrenal gland1 supporting datasetMogstm1(KOMP)VlcgheterozygoteEarly adultN/A * 
absent lymph nodes2 supporting datasetsMogstm1(KOMP)VlcgheterozygoteEarly adultN/A * 
embryonic lethality prior to organogenesis1 supporting datasetMogstm1.1(KOMP)VlcghomozygoteE9.5N/A * 
preweaning lethality, complete penetrance3 supporting datasetsMogstm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
abnormal pancreas morphology2 supporting datasetsMogstm1(KOMP)VlcgheterozygoteEarly adultN/A * 
preweaning lethality, complete penetrance3 supporting datasetsMogstm1(KOMP)VlcghomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Mogstm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Mogstm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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