Nampt | nicotinamide phosphoribosyltransferase
Physiological systems
22 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Nervous system Mortality/aging
20 No significant impact
2 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
47Embryo tissues
| abnormal brain morphology | 1 supporting dataset | Nampttm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Nampttm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Nampttm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * | ||
| hydrocephaly | 1 supporting dataset | Nampttm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * |
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| adrenal gland | heterozygote | Section images | 50% (1/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | Section images | 50% (1/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 100% (2/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Nampt mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Nampt.
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| Nampttm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Nampttm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Nampttm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |