Cacna2d2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2

GeneMGI:1929813Synonyms: a2d2

Physiological systems

22 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Adipose tissue Embryo Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system Renal/urinary system

9 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:24Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



female infertility	1 supporting dataset	Cacna2d2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
small kidney	1 supporting dataset	Cacna2d2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal kidney morphology	2 supporting datasets	Cacna2d2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
small seminal vesicle	1 supporting dataset	Cacna2d2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal seminal vesicle morphology	1 supporting dataset	Cacna2d2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Cacna2d2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal placenta morphology	1 supporting dataset	Cacna2d2^em1(IMPC)Mbp	homozygote	E18.5	N/A ^*
enlarged spleen	1 supporting dataset	Cacna2d2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
no spontaneous movement	1 supporting dataset	Cacna2d2^em1(IMPC)Mbp	heterozygote	E18.5	N/A ^*
no spontaneous movement	1 supporting dataset	Cacna2d2^em1(IMPC)Mbp	homozygote	E18.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cacna2d2.

Associated images

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Histopathology

There is no histopathology data found for Cacna2d2.

IMPC related publications

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External links

No external links available for Cacna2d2.

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*Cacna2d2^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Cacna2d2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Cacna2d2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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