Anapc7 | anaphase promoting complex subunit 7

GeneMGI:1929711Synonyms: APC7, prediabetic NOD sera-reactive autoantigen

Physiological systems

17 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Adipose tissue Hematopoietic system Behavior/neurological Skeleton Mortality/aging Cardiovascular system

9 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



prolonged RR interval	1 supporting dataset	Anapc7^em1(IMPC)J	homozygote	Early adult	5.84x10^-9
decreased bone mineral content	1 supporting dataset	Anapc7^em1(IMPC)J	homozygote	Early adult	1.88x10^-6
increased total body fat amount	2 supporting datasets	Anapc7^em1(IMPC)J	homozygote	Early adult	1.06x10^-6
preweaning lethality, incomplete penetrance	1 supporting dataset	Anapc7^em1(IMPC)J	homozygote	Early adult	N/A ^*
decreased erythrocyte cell number	1 supporting dataset	Anapc7^em1(IMPC)J	homozygote	Early adult	7.37x10^-13
impaired glucose tolerance	1 supporting dataset	Anapc7^em1(IMPC)J	homozygote	Early adult	1.62x10^-5
abnormal bone structure	1 supporting dataset	Anapc7^em1(IMPC)J	homozygote	Early adult	1.62x10^-8
decreased mean corpuscular volume	1 supporting dataset	Anapc7^em1(IMPC)J	homozygote	Early adult	2.37x10^-8
decreased mean corpuscular hemoglobin	1 supporting dataset	Anapc7^em1(IMPC)J	homozygote	Early adult	4.55x10^-7
decreased locomotor activity	1 supporting dataset	Anapc7^em1(IMPC)J	homozygote	Early adult	9.9x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Anapc7.

Associated images

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Histopathology

There is no histopathology data found for Anapc7.

IMPC related publications

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External links

No external links available for Anapc7.

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*Anapc7^em1(IMPC)J*	Exon Deletion	‌	mouse
*Anapc7^{tm45056(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Anapc7^{tm45056(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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