Atl2 | atlastin GTPase 2

GeneMGI:1929492Synonyms: Aip-2, Arl6ip2, +1 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Immune system Adipose tissue Growth/size/body region Hematopoietic system Mortality/aging

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

21Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased mean corpuscular volume	1 supporting dataset	Atl2^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	3.76x10^-5
increased total body fat amount	1 supporting dataset	Atl2^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	4.65x10^-7
decreased red blood cell distribution width	1 supporting dataset	Atl2^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	4.27x10^-7
increased lymphocyte cell number	1 supporting dataset	Atl2^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	6.92x10^-8
decreased spleen weight	1 supporting dataset	Atl2^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	9.7x10^-5
decreased lean body mass	1 supporting dataset	Atl2^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	3.67x10^-5
embryonic lethality prior to organogenesis	1 supporting dataset	Atl2^{tm2b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Atl2^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased neutrophil cell number	1 supporting dataset	Atl2^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	2.42x10^-10
increased hemoglobin content	1 supporting dataset	Atl2^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	3.92x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Atl2.

Associated images

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Histopathology

There is no histopathology data found for Atl2.

IMPC related publications

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External links

No external links available for Atl2.

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*Atl2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Atl2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Atl2^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Atl2^{tm2b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Atl2^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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