Myoz1 | myozenin 1

GeneMGI:1929471Synonyms: calsarcin-2, FATZ, +1 more

Physiological systems

23 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Digestive/alimentary Limbs/digits/tail Hematopoietic system Behavior/neurological Renal/urinary system

12 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



decreased grip strength	4 supporting datasets	Myoz1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.85x10^-6
polycystic kidney	1 supporting dataset	Myoz1^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
increased total body fat amount	1 supporting dataset	Myoz1^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	8.9x10^-5
increased marginal zone B cell number	1 supporting dataset	Myoz1^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	8.45x10^-5
abnormal urination	1 supporting dataset	Myoz1^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	7.7x10^-5
oligodactyly	1 supporting dataset	Myoz1^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	2.24x10^-11
abnormal lean body mass	1 supporting dataset	Myoz1^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	6.2x10^-9
enlarged seminal vesicle	1 supporting dataset	Myoz1^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
enlarged cecum	2 supporting datasets	Myoz1^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
decreased circulating creatinine level	1 supporting dataset	Myoz1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.81x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Myoz1.

Associated images

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Histopathology

There is no histopathology data found for Myoz1.

IMPC related publications

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External links

No external links available for Myoz1.

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*Myoz1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Myoz1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Myoz1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Myoz1^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Myoz1^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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