Cib2 | calcium and integrin binding family member 2
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Hearing/vestibular/ear Nervous system Hematopoietic system Behavior/neurological
13 No significant impact
5 Not tested
Data collections
Gene metrics:12Significant phenotypes
4Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| abnormal startle reflex | 1 supporting dataset | Cib2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 7.54x10-21 | ||
| tremors | 1 supporting dataset | Cib2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.6x10-5 | ||
| increased basophil cell number | 1 supporting dataset | Cib2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.59x10-5 | ||
| abnormal auditory brainstem response | 4 supporting datasets | Cib2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.79x10-5 | ||
| decreased prepulse inhibition | 6 supporting datasets | Cib2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 7x10-21 | ||
| limb grasping | 1 supporting dataset | Cib2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.01x10-6 | ||
| increased circulating cholesterol level | 1 supporting dataset | Cib2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.14x10-6 | ||
| increased circulating triglyceride level | 1 supporting dataset | Cib2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.17x10-7 | ||
| abnormal ear morphology | 1 supporting dataset | Cib2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.72x10-10 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Cib2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 9.99x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (3/3) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/3) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (3/3) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Cib2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cib2.
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| Cib2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Cib2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cib2tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Cib2tm1c(EUCOMM)Wtsi | Wild type floxed exon (post-Flp) | | mouse |
| Cib2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |