Cib2 | calcium and integrin binding family member 2

GeneMGI:1929293Synonyms: calcium binding protein Kip2, 2810434I23Rik

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hearing/vestibular/ear Nervous system Hematopoietic system Behavior/neurological

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

4Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



abnormal startle reflex	1 supporting dataset	Cib2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.54x10^-21
tremors	1 supporting dataset	Cib2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.6x10^-5
increased basophil cell number	1 supporting dataset	Cib2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.59x10^-5
abnormal auditory brainstem response	4 supporting datasets	Cib2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.79x10^-5
decreased prepulse inhibition	6 supporting datasets	Cib2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7x10^-21
limb grasping	1 supporting dataset	Cib2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.01x10^-6
increased circulating cholesterol level	1 supporting dataset	Cib2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.14x10^-6
increased circulating triglyceride level	1 supporting dataset	Cib2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.17x10^-7
abnormal ear morphology	1 supporting dataset	Cib2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.72x10^-10
increased circulating HDL cholesterol level	1 supporting dataset	Cib2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.99x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cib2.

Associated images

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Histopathology

There is no histopathology data found for Cib2.

IMPC related publications

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External links

No external links available for Cib2.

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*Cib2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Cib2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Cib2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cib2^{tm1c(EUCOMM)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Cib2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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