Mtch2 | mitochondrial carrier 2

GeneMGI:1929260Synonyms: HSPC032, 4930539J07Rik, +1 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Immune system Hematopoietic system Skeleton Mortality/aging

16 No significant impact

4 Not tested

Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
21Embryo tissues

Phenotypes

embryonic lethality prior to tooth bud stage1 supporting datasetMtch2tm1b(EUCOMM)HmguhomozygoteE12.5N/A * 
increased monocyte cell number2 supporting datasetsMtch2tm1b(EUCOMM)HmguheterozygoteEarly adult7.83x10-6 
abnormal vertebrae morphology1 supporting datasetMtch2tm1b(EUCOMM)HmguheterozygoteEarly adult4.87x10-5 
preweaning lethality, complete penetrance1 supporting datasetMtch2tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Mtch2tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell
Mtch2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Mtch2tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Mtch2tm1e(EUCOMM)HmguTargeted, non-conditional allelees cell

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