Mtch2 | mitochondrial carrier 2
Physiological systems
20 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Immune system Hematopoietic system Skeleton Mortality/aging
16 No significant impact
4 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
21Embryo tissues
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Mtch2tm1b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| increased monocyte cell number | 2 supporting datasets | Mtch2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 7.83x10-6 | ||
| abnormal vertebrae morphology | 1 supporting dataset | Mtch2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 4.87x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Mtch2tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Mtch2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mtch2.
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| Mtch2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Mtch2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Mtch2tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Mtch2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |