Cldn18 | claudin 18

GeneMGI:1929209

Physiological systems

21 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Reproductive system Growth/size/body region Respiratory system Hematopoietic system

17 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



enlarged lung	2 supporting datasets	Cldn18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal lung morphology	2 supporting datasets	Cldn18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal uterus morphology	1 supporting dataset	Cldn18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased lung weight	2 supporting datasets	Cldn18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.43x10^-7
increased red blood cell distribution width	1 supporting dataset	Cldn18^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.48x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cldn18.

Associated images

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Histopathology

There is no histopathology data found for Cldn18.

IMPC related publications

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External links

No external links available for Cldn18.

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*Cldn18^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Cldn18^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse

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