Izumo1r | IZUMO1 receptor, JUNO
Physiological systems
18 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Adipose tissue Growth/size/body region Hematopoietic system Cardiovascular system
12 No significant impact
6 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:152Adult tissues
25Embryo tissues
| female infertility | 1 supporting dataset | Izumo1rtm2a(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| decreased circulating fructosamine level | 1 supporting dataset | Izumo1rtm2a(KOMP)Wtsi | homozygote | Early adult | 4.45x10-5 | ||
| increased circulating chloride level | 1 supporting dataset | Izumo1rtm2a(KOMP)Wtsi | homozygote | Early adult | 4.99x10-6 | ||
| increased lean body mass | 2 supporting datasets | Izumo1rtm2a(KOMP)Wtsi | homozygote | Early adult | 3.6x10-6 | ||
| decreased total body fat amount | 1 supporting dataset | Izumo1rtm2a(KOMP)Wtsi | homozygote | Early adult | 3.75x10-5 | ||
| decreased circulating glucose level | 1 supporting dataset | Izumo1rtm2a(KOMP)Wtsi | homozygote | Early adult | 1.24x10-5 | ||
| increased heart weight | 1 supporting dataset | Izumo1rtm2a(KOMP)Wtsi | homozygote | Early adult | 2.12x10-5 | ||
| female infertility | 1 supporting dataset | Izumo1rtm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| decreased circulating amylase level | 1 supporting dataset | Izumo1rtm2a(KOMP)Wtsi | homozygote | Early adult | 1.23x10-5 | ||
| increased red blood cell distribution width | 1 supporting dataset | Izumo1rtm2a(KOMP)Wtsi | homozygote | Early adult | 3.25x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/4) | 0.7% (4/570) |
| adrenal gland | homozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/4) | 0.19% (1/533) |
| aorta | homozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | n/a | 0% (0/394) |
| bone | homozygote | Wholemount images | n/a | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/4) | 0.86% (5/579) |
| brain | homozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/4) | 0.41% (2/490) |
| brainstem | homozygote | n/a | 0% (0/2) | 0.41% (2/490) |
Human diseases caused by Izumo1r mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Izumo1r.
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| Izumo1rtm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Izumo1rtm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Izumo1rtm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Izumo1rtm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Izumo1rtm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |