Kcnd3 | potassium voltage-gated channel, Shal-related family, member 3

GeneMGI:1928743Synonyms: Kv4.3, potassium channel Kv4.3L, +1 more

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Behavior/neurological Skeleton

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:8Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased thigmotaxis4 supporting datasetsKcnd3em1(IMPC)JhomozygoteEarly adult5.85x10-8 
decreased exploration in new environment1 supporting datasetKcnd3em1(IMPC)JhomozygoteEarly adult1.7x10-6 
hyperactivity1 supporting datasetKcnd3em1(IMPC)JhomozygoteEarly adult4.98x10-5 
abnormal startle reflex1 supporting datasetKcnd3em1(IMPC)JhomozygoteLate adult2.92x10-5 
hyperactivity7 supporting datasetsKcnd3em1(IMPC)JhomozygoteLate adult1.69x10-8 
increased vertical activity1 supporting datasetKcnd3em1(IMPC)JhomozygoteEarly adult2.56x10-18 
decreased locomotor activity1 supporting datasetKcnd3em1(IMPC)JhomozygoteEarly adult1.12x10-6 
increased bone mineral content1 supporting datasetKcnd3em1(IMPC)JhomozygoteLate adult3.97x10-6 
decreased blood urea nitrogen level1 supporting datasetKcnd3em1(IMPC)JhomozygoteEarly adult4.68x10-5 
increased vertical activity1 supporting datasetKcnd3em1(IMPC)JhomozygoteLate adult5.97x10-8 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Kcnd3em1(IMPC)JExon Deletionmouse
Kcnd3tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Kcnd3tm44931(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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