Kcnd3 | potassium voltage-gated channel, Shal-related family, member 3
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological Skeleton
15 No significant impact
6 Not tested
Data collections
Gene metrics:8Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased thigmotaxis | 4 supporting datasets | Kcnd3em1(IMPC)J | homozygote | Early adult | 5.85x10-8 | ||
| decreased exploration in new environment | 1 supporting dataset | Kcnd3em1(IMPC)J | homozygote | Early adult | 1.7x10-6 | ||
| hyperactivity | 1 supporting dataset | Kcnd3em1(IMPC)J | homozygote | Early adult | 4.98x10-5 | ||
| abnormal startle reflex | 1 supporting dataset | Kcnd3em1(IMPC)J | homozygote | Late adult | 2.92x10-5 | ||
| hyperactivity | 7 supporting datasets | Kcnd3em1(IMPC)J | homozygote | Late adult | 1.69x10-8 | ||
| increased vertical activity | 1 supporting dataset | Kcnd3em1(IMPC)J | homozygote | Early adult | 2.56x10-18 | ||
| decreased locomotor activity | 1 supporting dataset | Kcnd3em1(IMPC)J | homozygote | Early adult | 1.12x10-6 | ||
| increased bone mineral content | 1 supporting dataset | Kcnd3em1(IMPC)J | homozygote | Late adult | 3.97x10-6 | ||
| decreased blood urea nitrogen level | 1 supporting dataset | Kcnd3em1(IMPC)J | homozygote | Early adult | 4.68x10-5 | ||
| increased vertical activity | 1 supporting dataset | Kcnd3em1(IMPC)J | homozygote | Late adult | 5.97x10-8 |
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Human diseases caused by Kcnd3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Kcnd3.
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| Kcnd3em1(IMPC)J | Exon Deletion | | mouse |
| Kcnd3tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Kcnd3tm44931(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |