Stx5a | syntaxin 5A

GeneMGI:1928483Synonyms: syntaxin 5, D19Ertd627e, +1 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Nervous system Vision/eye Hematopoietic system Mortality/aging Cardiovascular system

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal retina morphology	1 supporting dataset	Stx5a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.21x10^-5
abnormal optic disk morphology	1 supporting dataset	Stx5a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.88x10^-8
persistence of hyaloid vascular system	1 supporting dataset	Stx5a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.7x10^-13
preweaning lethality, complete penetrance	1 supporting dataset	Stx5a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased total retina thickness	1 supporting dataset	Stx5a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.55x10^-6
increased red blood cell distribution width	1 supporting dataset	Stx5a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.67x10^-5
abnormal retina blood vessel morphology	1 supporting dataset	Stx5a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.51x10^-7
abnormal retina vasculature morphology	1 supporting dataset	Stx5a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.61x10^-7
abnormal vitreous body morphology	1 supporting dataset	Stx5a^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.7x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Stx5a.

Associated images

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Histopathology

There is no histopathology data found for Stx5a.

IMPC related publications

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External links

No external links available for Stx5a.

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*Stx5a^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Stx5a^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Stx5a^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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