Mrps25 | mitochondrial ribosomal protein S25
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Mortality/aging Cardiovascular system
15 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
1Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| increased circulating sodium level | 1 supporting dataset | Mrps25tm1.1(KOMP)Vlcg | heterozygote | Early adult | 4.38x10-5 | ||
| increased heart weight | 1 supporting dataset | Mrps25tm1.1(KOMP)Vlcg | heterozygote | Early adult | 7.15x10-6 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Mrps25tm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Mrps25tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Mrps25tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| decreased circulating glucose level | 1 supporting dataset | Mrps25tm1.1(KOMP)Vlcg | heterozygote | Early adult | 9.63x10-5 | ||
| decreased circulating calcium level | 1 supporting dataset | Mrps25tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.21x10-5 |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Mrps25 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mrps25.
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| Mrps25tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Mrps25tm1(NCOM)Cmhd | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Mrps25tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Mrps25tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Mrps25tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |