Mrps22 | mitochondrial ribosomal protein S22

GeneMGI:1928137Synonyms: 3100002P07Rik, Rpms22

Physiological systems

18 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Mortality/aging

10 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

4Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased bone mineral density	1 supporting dataset	Mrps22^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	3.87x10^-5
increased total body fat amount	2 supporting datasets	Mrps22^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	6.6x10^-8
decreased bone mineral content	2 supporting datasets	Mrps22^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.17x10^-6
decreased lean body mass	1 supporting dataset	Mrps22^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	5.55x10^-5
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Mrps22^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	3.11x10^-5
increased leukocyte cell number	1 supporting dataset	Mrps22^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	8.3x10^-5
embryonic lethality prior to organogenesis	1 supporting dataset	Mrps22^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Mrps22^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
decreased circulating creatinine level	1 supporting dataset	Mrps22^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	7.81x10^-5
hyperactivity	1 supporting dataset	Mrps22^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	3.66x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mrps22.

Associated images

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Histopathology

There is no histopathology data found for Mrps22.

IMPC related publications

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External links

No external links available for Mrps22.

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*Mrps22^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Mrps22^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Mrps22^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Mrps22^{tm84087(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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