Mrps22 | mitochondrial ribosomal protein S22
Physiological systems
18 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Mortality/aging
10 No significant impact
6 Not tested
Data collections
Gene metrics:10Significant phenotypes
4Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| decreased bone mineral density | 1 supporting dataset | Mrps22tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.87x10-5 | ||
| increased total body fat amount | 2 supporting datasets | Mrps22tm1.1(KOMP)Vlcg | heterozygote | Early adult | 6.6x10-8 | ||
| decreased bone mineral content | 2 supporting datasets | Mrps22tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.17x10-6 | ||
| decreased lean body mass | 1 supporting dataset | Mrps22tm1.1(KOMP)Vlcg | heterozygote | Early adult | 5.55x10-5 | ||
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Mrps22tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.11x10-5 | ||
| increased leukocyte cell number | 1 supporting dataset | Mrps22tm1.1(KOMP)Vlcg | heterozygote | Early adult | 8.3x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Mrps22tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Mrps22tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| decreased circulating creatinine level | 1 supporting dataset | Mrps22tm1.1(KOMP)Vlcg | heterozygote | Early adult | 7.81x10-5 | ||
| hyperactivity | 1 supporting dataset | Mrps22tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.66x10-6 |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Mrps22 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mrps22.
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| Mrps22tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Mrps22tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Mrps22tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Mrps22tm84087(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |