Sp5 | trans-acting transcription factor 5

GeneMGI:1927715

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Hematopoietic system Behavior/neurological

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

46Embryo tissues

Phenotypes

Phy. System:

Life Stage:



hyperactivity	5 supporting datasets	Sp5^{tm1b(KOMP)Wtsi}	homozygote	Late adult	5.23x10^-10
increased circulating alanine transaminase level	1 supporting dataset	Sp5^{tm1b(KOMP)Wtsi}	homozygote	Late adult	7.09x10^-5
increased vertical activity	1 supporting dataset	Sp5^{tm1b(KOMP)Wtsi}	homozygote	Late adult	1.12x10^-5
increased grip strength	1 supporting dataset	Sp5^{tm1b(KOMP)Wtsi}	homozygote	Late adult	2.93x10^-5
abnormal vibrissa morphology	1 supporting dataset	Sp5^{tm1b(KOMP)Wtsi}	homozygote	Late adult	2x10^-5
decreased hematocrit	1 supporting dataset	Sp5^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.88x10^-5
decreased fasting circulating glucose level	1 supporting dataset	Sp5^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.91x10^-7
hyperactivity	1 supporting dataset	Sp5^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.57x10^-9

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sp5.

Associated images

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Histopathology

There is no histopathology data found for Sp5.

IMPC related publications

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External links

No external links available for Sp5.

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*Sp5^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Sp5^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Sp5^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Sp5^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell

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