Sp5 | trans-acting transcription factor 5
GeneMGI:1927715
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Hematopoietic system Behavior/neurological
14 No significant impact
6 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
46Embryo tissues
| hyperactivity | 5 supporting datasets | Sp5tm1b(KOMP)Wtsi | homozygote | Late adult | 5.23x10-10 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Sp5tm1b(KOMP)Wtsi | homozygote | Late adult | 7.09x10-5 | ||
| increased vertical activity | 1 supporting dataset | Sp5tm1b(KOMP)Wtsi | homozygote | Late adult | 1.12x10-5 | ||
| increased grip strength | 1 supporting dataset | Sp5tm1b(KOMP)Wtsi | homozygote | Late adult | 2.93x10-5 | ||
| abnormal vibrissa morphology | 1 supporting dataset | Sp5tm1b(KOMP)Wtsi | homozygote | Late adult | 2x10-5 | ||
| decreased hematocrit | 1 supporting dataset | Sp5tm1b(KOMP)Wtsi | homozygote | Early adult | 7.88x10-5 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Sp5tm1b(KOMP)Wtsi | homozygote | Early adult | 7.91x10-7 | ||
| hyperactivity | 1 supporting dataset | Sp5tm1b(KOMP)Wtsi | homozygote | Early adult | 1.57x10-9 |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Sp5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Sp5.
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| Sp5tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Sp5tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Sp5tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Sp5tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |