Bloc1s6 | biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Immune system Integument Vision/eye Behavior/neurological
14 No significant impact
4 Not tested
Data collections
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal coat/hair pigmentation | 3 supporting datasets | Bloc1s6em1(IMPC)Mbp | homozygote | Early adult | 2.32x10-15 | ||
| abnormal eye morphology | 2 supporting datasets | Bloc1s6em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal skin morphology | 2 supporting datasets | Bloc1s6em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| hyperactivity | 2 supporting datasets | Bloc1s6em1(IMPC)Mbp | homozygote | Early adult | 5.7x10-5 | ||
| increased circulating serum albumin level | 1 supporting dataset | Bloc1s6em1(IMPC)Mbp | homozygote | Early adult | 1.47x10-5 | ||
| abnormal lymph node morphology | 1 supporting dataset | Bloc1s6em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| improved glucose tolerance | 1 supporting dataset | Bloc1s6em1(IMPC)Mbp | homozygote | Early adult | 8.7x10-5 |
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Human diseases caused by Bloc1s6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Bloc1s6.
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| Bloc1s6em1(IMPC)Mbp | Exon Deletion | | mouse |
| Bloc1s6tm271492(L1L2_6XOspnEnh_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Bloc1s6tm271492(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |