Bloc1s6 | biogenesis of lysosomal organelles complex-1, subunit 6, pallidin

GeneMGI:1927580Synonyms: BLOC-1, BLOC-1 subunit, +1 more

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Pigmentation Immune system Integument Vision/eye Behavior/neurological

14 No significant impact

4 Not tested

Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal coat/hair pigmentation3 supporting datasetsBloc1s6em1(IMPC)MbphomozygoteEarly adult2.32x10-15 
abnormal eye morphology2 supporting datasetsBloc1s6em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal skin morphology2 supporting datasetsBloc1s6em1(IMPC)MbphomozygoteEarly adultN/A * 
hyperactivity2 supporting datasetsBloc1s6em1(IMPC)MbphomozygoteEarly adult5.7x10-5 
increased circulating serum albumin level1 supporting datasetBloc1s6em1(IMPC)MbphomozygoteEarly adult1.47x10-5 
abnormal lymph node morphology1 supporting datasetBloc1s6em1(IMPC)MbphomozygoteEarly adultN/A * 
improved glucose tolerance1 supporting datasetBloc1s6em1(IMPC)MbphomozygoteEarly adult8.7x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Bloc1s6em1(IMPC)MbpExon Deletionmouse
Bloc1s6tm271492(L1L2_6XOspnEnh_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Bloc1s6tm271492(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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