Gmnn | geminin
Physiological systems
20 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Vision/eye Mortality/aging
18 No significant impact
4 Not tested
Data collections
Gene metrics:3Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| abnormal lens morphology | 1 supporting dataset | Gmnntm1a(KOMP)Wtsi | heterozygote | Early adult | 9.09x10-8 | ||
| cataract | 1 supporting dataset | Gmnntm1a(KOMP)Wtsi | heterozygote | Early adult | 7.19x10-8 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Gmnntm1a(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 50% (1/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Gmnn mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Gmnn.
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| Gmnntm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Gmnntm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Gmnntm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |