Nt5c3 | 5'-nucleotidase, cytosolic III
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Integument Vision/eye Hematopoietic system Skeleton
12 No significant impact
7 Not tested
Data collections
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased red blood cell distribution width | 1 supporting dataset | Nt5c3em1(IMPC)Tcp | homozygote | Early adult | 8.5x10-10 | ||
| enlarged lymph nodes | 1 supporting dataset | Nt5c3em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| abnormal skin morphology | 2 supporting datasets | Nt5c3em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| abnormal lens morphology | 1 supporting dataset | Nt5c3em1(IMPC)Tcp | homozygote | Early adult | 1x10-5 | ||
| abnormal eye morphology | 1 supporting dataset | Nt5c3em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| cataract | 1 supporting dataset | Nt5c3em1(IMPC)Tcp | homozygote | Early adult | 1.53x10-5 | ||
| abnormal sternum morphology | 1 supporting dataset | Nt5c3em1(IMPC)Tcp | homozygote | Early adult | N/A * |
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Human diseases caused by Nt5c3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Nt5c3.
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| Nt5c3em1(IMPC)Tcp | Exon Deletion | | mouse |
| Nt5c3tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Nt5c3tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Nt5c3tm43034(L1L2_st0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |