Ubash3a | ubiquitin associated and SH3 domain containing, A
Physiological systems
20 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Behavior/neurological Cardiovascular system
16 No significant impact
4 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues
| decreased circulating triglyceride level | 1 supporting dataset | Ubash3atm1b(KOMP)Wtsi | homozygote | Early adult | 2.53x10-5 | ||
| cataract | 1 supporting dataset | Ubash3atm1b(KOMP)Wtsi | homozygote | Early adult | 8.58x10-5 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Ubash3atm1b(KOMP)Wtsi | homozygote | Early adult | 7.7x10-6 | ||
| abnormal lens morphology | 1 supporting dataset | Ubash3atm1b(KOMP)Wtsi | homozygote | Early adult | 3.21x10-6 | ||
| decreased grip strength | 2 supporting datasets | Ubash3atm1a(KOMP)Wtsi | homozygote | Early adult | 7.79x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Wholemount images | 50% (1/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
Human diseases caused by Ubash3a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ubash3a.
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| Ubash3atm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ubash3atm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ubash3atm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |