Ascc3 | activating signal cointegrator 1 complex subunit 3
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Adipose tissue Growth/size/body region Limbs/digits/tail Vision/eye Behavior/neurological Skeleton Mortality/aging
13 No significant impact
4 Not tested
Data collections
Gene metrics:7Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased lean body mass | 1 supporting dataset | Ascc3tm1a(EUCOMM)Hmgu | heterozygote | Early adult | 5.63x10-5 | ||
| increased total body fat amount | 1 supporting dataset | Ascc3tm1a(EUCOMM)Hmgu | heterozygote | Early adult | 7.41x10-5 | ||
| increased startle reflex | 1 supporting dataset | Ascc3tm1a(EUCOMM)Hmgu | heterozygote | Early adult | 5.49x10-6 | ||
| long tibia | 1 supporting dataset | Ascc3tm1a(EUCOMM)Hmgu | heterozygote | Early adult | 9.73x10-8 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Ascc3tm1a(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Ascc3em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| abnormal retina morphology | 1 supporting dataset | Ascc3tm1a(EUCOMM)Hmgu | heterozygote | Early adult | 3.54x10-5 | ||
| increased lean body mass | 1 supporting dataset | Ascc3tm1a(EUCOMM)Hmgu | heterozygote | Early adult | 3.82x10-5 |
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Human diseases caused by Ascc3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ascc3.
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| Ascc3em1(IMPC)Bay | Exon Deletion | | mouse |
| Ascc3tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ascc3tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |