Mrps5 | mitochondrial ribosomal protein S5
GeneMGI:1924971
Physiological systems
18 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Behavior/neurological Mortality/aging
16 No significant impact
6 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Mrps5tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * | ||
| decreased grip strength | 1 supporting dataset | Mrps5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.22x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Mrps5tm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Mrps5tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Mrps5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mrps5.
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| Mrps5tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Mrps5tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Mrps5tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Mrps5tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Mrps5tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |