Ehmt1 | euchromatic histone methyltransferase 1

GeneMGI:1924933Synonyms: KMT1D, 9230102N17Rik

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Mortality/aging

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal behavior	1 supporting dataset	Ehmt1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.97x10^-5
preweaning lethality, complete penetrance	2 supporting datasets	Ehmt1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased locomotor activity	5 supporting datasets	Ehmt1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.28x10^-9
decreased circulating serum albumin level	1 supporting dataset	Ehmt1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.75x10^-6
increased thigmotaxis	2 supporting datasets	Ehmt1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.93x10^-5
decreased circulating creatinine level	1 supporting dataset	Ehmt1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.09x10^-5
increased anxiety-related response	1 supporting dataset	Ehmt1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.07x10^-5
increased neutrophil cell number	1 supporting dataset	Ehmt1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.75x10^-5
decreased exploration in new environment	1 supporting dataset	Ehmt1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.7x10^-5
increased circulating cholesterol level	1 supporting dataset	Ehmt1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.7x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ehmt1.

Associated images

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Histopathology

There is no histopathology data found for Ehmt1.

IMPC related publications

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External links

No external links available for Ehmt1.

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*Ehmt1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ehmt1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ehmt1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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