Prdm8 | PR domain containing 8

GeneMGI:1924880

Physiological systems

21 / 24 physiological systems tested

14 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Hematopoietic system Craniofacial Cardiovascular system Homeostasis/metabolism Nervous system Vision/eye Respiratory system Behavior/neurological Skeleton

7 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:25Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased airway resistance	1 supporting dataset	Prdm8^{em1(IMPC)Wtsi}	heterozygote	Early adult	8.37x10^-6
impaired glucose tolerance	1 supporting dataset	Prdm8^{em1(IMPC)Wtsi}	homozygote	Early adult	3.31x10^-7
hyperactivity	3 supporting datasets	Prdm8^{em1(IMPC)Wtsi}	homozygote	Early adult	2.8x10^-9
small heart	1 supporting dataset	Prdm8^{em1(IMPC)Wtsi}	homozygote	Early adult	N/A ^*
abnormal tooth morphology	1 supporting dataset	Prdm8^{em1(IMPC)Wtsi}	heterozygote	Early adult	N/A ^*
enlarged thymus	2 supporting datasets	Prdm8^{em1(IMPC)Wtsi}	heterozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Prdm8^{em1(IMPC)Wtsi}	homozygote	Early adult	N/A ^*
abnormal heart left ventricle morphology	2 supporting datasets	Prdm8^{em1(IMPC)Wtsi}	homozygote	Early adult	1.3x10^-5
increased lung elastance	1 supporting dataset	Prdm8^{em1(IMPC)Wtsi}	homozygote	Early adult	9.18x10^-5
abnormal uterus morphology	1 supporting dataset	Prdm8^{em1(IMPC)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Prdm8.

Associated images

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Histopathology

There is no histopathology data found for Prdm8.

IMPC related publications

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External links

No external links available for Prdm8.

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*Prdm8^{em1(IMPC)Wtsi}*	Exon Deletion	‌	mouse
*Prdm8^em1H*	Insertion	‌	mouse
*Prdm8^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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