Apex2 | apurinic/apyrimidinic endonuclease 2

GeneMGI:1924872Synonyms: Ape2, C430040P13Rik

Physiological systems

16 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Pigmentation Immune system Integument Growth/size/body region Hematopoietic system Behavior/neurological Craniofacial

9 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased locomotor activity	3 supporting datasets	Apex2^em1(IMPC)H	homozygote	Late adult	1.26x10^-7
increased neutrophil cell number	1 supporting dataset	Apex2^em1(IMPC)H	homozygote	Late adult	3.53x10^-6
abnormal snout morphology	1 supporting dataset	Apex2^em1(IMPC)H	homozygote	Early adult	9.35x10^-17
increased mean corpuscular volume	1 supporting dataset	Apex2^em1(IMPC)H	homozygote	Late adult	5.55x10^-5
decreased erythrocyte cell number	1 supporting dataset	Apex2^em1(IMPC)H	homozygote	Late adult	3.76x10^-5
abnormal coat/hair pigmentation	1 supporting dataset	Apex2^em1(IMPC)H	hemizygote	Early adult	1.24x10^-5
decreased lymphocyte cell number	1 supporting dataset	Apex2^em1(IMPC)H	homozygote	Late adult	6.32x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Apex2.

Associated images

Loading...

Histopathology

There is no histopathology data found for Apex2.

IMPC related publications

Loading...

External links

No external links available for Apex2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Apex2^em1(IMPC)H*	Exon Deletion	‌	mouse
*Apex2^em2(IMPC)H*	Exon Deletion	‌	mouse
*Apex2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Apex2^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Apex2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Apex2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

My Genes