Mboat7 | membrane bound O-acyltransferase domain containing 7
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Hematopoietic system Mortality/aging
14 No significant impact
4 Not tested
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| increased lymphocyte cell number | 1 supporting dataset | Mboat7tm1b(KOMP)Wtsi | heterozygote | Early adult | 9.53x10-6 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Mboat7tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| decreased lean body mass | 1 supporting dataset | Mboat7tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.4x10-5 | ||
| small seminal vesicle | 1 supporting dataset | Mboat7tm1b(KOMP)Wtsi | heterozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Mboat7 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mboat7.
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| Mboat7tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Mboat7tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Mboat7tm1c(KOMP)Wtsi | Wild type floxed exon (post-Flp) | | mouse |
| Mboat7tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |