Spns3 | SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)
Physiological systems
18 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Reproductive system Immune system Growth/size/body region Hematopoietic system Skeleton Renal/urinary system
12 No significant impact
6 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal sternum morphology | 1 supporting dataset | Spns3em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| abnormal uterus morphology | 1 supporting dataset | Spns3em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| enlarged urinary bladder | 1 supporting dataset | Spns3em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| increased eosinophil cell number | 1 supporting dataset | Spns3em1(IMPC)Tcp | homozygote | Early adult | 1.97x10-6 | ||
| increased red blood cell distribution width | 1 supporting dataset | Spns3em1(IMPC)Tcp | homozygote | Early adult | 1.78x10-5 | ||
| enlarged kidney | 1 supporting dataset | Spns3em1(IMPC)Tcp | homozygote | Early adult | N/A * |
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Human diseases caused by Spns3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Spns3.
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| Spns3em1(IMPC)Tcp | Exon Deletion | | mouse |
| Spns3tm446(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Spns3tm446(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |