Kmt2e | lysine (K)-specific methyltransferase 2E

GeneMGI:1924825Synonyms: 1810033J14Rik, D230038D11Rik, +2 more

Physiological systems

15 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological

10 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased lean body mass	1 supporting dataset	Kmt2e^{tm1.2(IMPC)Wtsi}	heterozygote	Early adult	8.71x10^-6
absent pinna reflex	1 supporting dataset	Kmt2e^{tm1.2(IMPC)Wtsi}	heterozygote	Early adult	9.77x10^-6
increased mean corpuscular hemoglobin	1 supporting dataset	Kmt2e^{tm1.2(IMPC)Wtsi}	heterozygote	Early adult	1.26x10^-8
increased red blood cell distribution width	1 supporting dataset	Kmt2e^{tm1.2(IMPC)Wtsi}	heterozygote	Early adult	1.82x10^-5
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Kmt2e^{tm1.2(IMPC)Wtsi}	heterozygote	Early adult	3.01x10^-15
increased total body fat amount	1 supporting dataset	Kmt2e^{tm1.2(IMPC)Wtsi}	heterozygote	Early adult	3.16x10^-5
increased blood urea nitrogen level	1 supporting dataset	Kmt2e^{tm1.2(IMPC)Wtsi}	heterozygote	Early adult	4.77x10^-5
increased circulating insulin level	1 supporting dataset	Kmt2e^{tm1.2(IMPC)Wtsi}	heterozygote	Early adult	6.03x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Kmt2e.

Associated images

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Histopathology

There is no histopathology data found for Kmt2e.

IMPC related publications

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External links

No external links available for Kmt2e.

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*Kmt2e^{tm1(IMPC)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Kmt2e^{tm1.2(IMPC)Wtsi}*	Reporter-tagged deletion allele (post Flp, with no reporter and selection cassette)	‌	mouse
*Kmt2e^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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