Tram2 | translocating chain-associating membrane protein 2

GeneMGI:1924817Synonyms: C330003D03Rik

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Limbs/digits/tail Behavior/neurological Skeleton

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal spine curvature	1 supporting dataset	Tram2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.08x10^-5
abnormal radius morphology	1 supporting dataset	Tram2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	3.56x10^-8
abnormal joint morphology	1 supporting dataset	Tram2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.46x10^-16
decreased bone mineral density	1 supporting dataset	Tram2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	6.37x10^-16
decreased bone mineral content	1 supporting dataset	Tram2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.32x10^-9
absent pinna reflex	1 supporting dataset	Tram2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.99x10^-18
decreased circulating serum albumin level	1 supporting dataset	Tram2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.96x10^-5
abnormal ulna morphology	1 supporting dataset	Tram2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	3.53x10^-6
increased circulating amylase level	1 supporting dataset	Tram2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.63x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Tram2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	3.4x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tram2.

Associated images

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Histopathology

There is no histopathology data found for Tram2.

IMPC related publications

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External links

No external links available for Tram2.

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*Tram2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Tram2^{tm1c(KOMP)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Tram2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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